Is fibromyalgia a mitochondrial dysfunction?

Is fibromyalgia a mitochondrial dysfunction?

Our results suggest that FM has mitochondrial dysfunction, although it is unclear whether inactivity, obesity, aging, and pain are causes of, the results of, or coincidental to the mitochondrial dysfunction.

Is inflammation a mitochondrial dysfunction dependent event in fibromyalgia?

These results lead to the hypothesis that inflammation could be a mitochondrial dysfunction-dependent event implicated in the pathophysiology of FM in several patients indicating at mitochondria as a possible new therapeutic target.

What is fibromyalgia spectrum?

The spectrum of fibromyalgia ranges from mild symptomatology, requiring no medical attention, to severe, with disabling widespread pain and exhaustion. The progression from mild to severe symptoms is not well understood but does involve personal psychosocial factors.

Is mitochondrial disease painful?

Chronic pain is common in patients with mitochondrial disease. Pain due to mitochondrial disease is primarily of neuropathic nature. Distribution, intensity and type of pain are genetically determined.

How are mitochondrial disorders diagnosed?

Mitochondrial disease diagnosis There are various methods to examine if an individual has mitochondrial disease. These include genetic diagnostic testing, genetic or biochemical tests in affected tissues, such as muscle or liver, and other blood or urine based biochemical markers.

Is mitochondrial myopathy painful?

Sometimes, mitochondrial disease is associated with muscle cramps. In rare instances it can lead to muscle breakdown and pain after exercise. This breakdown causes leakage of a protein called myoglobin from the muscles into the urine (myoglobinuria).

Can you reverse mitochondrial damage?

There are no cures for mitochondrial diseases, but treatment can help reduce symptoms or slow the decline in health. Treatment varies from patient to patient and depends on the specific mitochondrial disease diagnosed and its severity.