Can osteoporosis causes lytic lesions?
Myeloma bone disease can cause the bones to become thinner and weaker (osteoporosis), and it can make holes appear in the bone (lytic lesions). The weakened bone is more likely to break under minor pressure or injury (pathologic fracture).
How serious is a lytic lesion?
Lytic lesions refer to areas of bone destruction that result in holes. They typically occur due to a disease, such as cancer. In some cases, they may result in painful fractures that can be disabling and require surgery to reinforce and stabilize the bone.
What benign conditions cause lytic lesions?
Benign lytic bone lesions showing no periostitis or pain need separate mention: fibrous dysplasia, enchondroma, non-ossifying fibroma, and solitary bone cyst. In the case of malignant bone tumors like primary or metastasis pain may be persistent, unrelated to activity due to the involvement of neurovascular structures.
Is there a link between osteoporosis and myeloma?
Up to 90% of patients with multiple myeloma will develop bone disease, specifically osteoporosis or lytic lesions, and bone pain is one of the commonest presentations of the disease. The principal mechanism for this is thought to be dysregulation of bone turnover via changes in the bone marrow microenvironment.
What is the treatment for lytic lesions?
Surgical treatment options for benign lytic lesions of the proximal femur include curettage, and bone grafting of the resulting defect with or without internal fixation. Most of these studies recommended either autogenous or allogenic bone graft.
Which cancers cause lytic bone lesions?
Other types that can cause bone lesions include:
- Breast cancer.
- Kidney cancer.
- Lung cancer.
- Prostate cancer.
- Thyroid cancer.
Do lytic lesions go away?
What are Lytic Lesions? Also known as bone lesions or osteolytic lesions, lytic lesions are spots of bone damage that result from cancerous plasma cells building up in your bone marrow. Your bones can’t break down and regrow (your doctor may call this remodel) as they should.
Do lytic lesions show up on bone scan?
Bone scans generally are not sensitive for lytic bone lesions, and patients who show multiple myeloma or lytic abnormalities on computed tomography (CT) or x-ray should not be referred for a bone scan.
Can a DEXA scan show myeloma?
Bone scintigraphy has no place in the routine staging of myeloma, although sequential DEXA scans are not recommended.
Can you biopsy a lytic lesion?
We conclude that ultrasonically guided fine-needle aspiration biopsy is a useful technique to obtain a pathological diagnosis in cases of lytic bone lesions that can be visualized with this imaging technique.
What conditions are mistaken for myeloma?
Conditions That Can Look Like Multiple Myeloma
- Arthritis.
- Back Injury.
- Pneumonia.
- Kidney Disease.
- Amyloidosis.
- Diabetes.
- Lyme Disease.
- Hypercalcemia.
Can multiple myeloma be mistaken for osteoarthritis?
Multiple myeloma can cause pain in the lower back and other areas. It may feel similar to arthritis, which presents as swelling, pain, or stiffness in the joints and may affect several joints of varying sizes around the body.
Does multiple myeloma cause osteoarthritis?
Joint involvement in myeloma is typically an oligoarthritis [1] or a polyarticular rheumatoid-like pattern, as seen in this case. Though individuals with myeloma are at greater risk of both septic arthritis and gouty arthritis [3], other pathophysiological mechanisms have been postulated to account for joint disease.
Can a bone density test detect multiple myeloma?
Diagnosing multiple myeloma includes blood work, a 24-hour urine collection, a bone marrow biopsy, imaging studies (such as x-rays, MRIs, PET scans) and bone density tests.
Can multiple myeloma be mistaken for arthritis?
Common Symptoms Related to Multiple Myeloma Diagnosing multiple myeloma may be difficult because it can mimic other illnesses, including arthritis, diabetes mellitus or influenza.