Is trastuzumab a cardiotoxic?
Despite enforcement of stringent patient enrollment criteria, trastuzumab-based regimens are still regarded as significant cardiotoxicity risk, although the numbers of cardiotoxic events from recent clinical studies are less than reported in earlier trials.
Is bevacizumab a cardiotoxic?
Background/Aim: Bevacizumab combined with standard chemotherapeutics has become a choice of treatment for several kinds of cancers. Hypertension, third-degree albuminuria, thrombosis and cardiotoxicity are the reported side-effects of bevacizumab. Among them, cardiotoxicity is a most severe, but rare outcome.
Does trastuzumab cause heart failure?
Symptomatic heart failure, a serious adverse effect of trastuzumab, occurs in 1% to 4% of patients treated with the antibody, whereas left ventricular ejection fraction declines substantially in 10% of patients.
How does trastuzumab affect the heart?
One of the most common side effects of trastuzumab treatment is cardiotoxicity manifested as heart failure, accompanied by a decrease in left ventricular ejection fraction (LVEF) or an asymptomatic decrease in LVEF.
Is trastuzumab cardiotoxicity reversible?
Cardiotoxicity from trastuzumab is largely reversible and therefore characterized as causing type II chemotherapy-related cardiac dysfunction.
Is Herceptin cardiotoxicity reversible?
Although the main cardiotoxicity of trastuzumab is only an asymptomatic decline in LVEF and is mostly reversible with interruption of trastuzumab or cardiac medication, some patients, especially those with cardiac risk factors, may rarely experience chronic heart failure or prolonged LVEF reduction.
Which chemotherapy drugs are cardiotoxic?
The most common chemotherapy drugs related to cardio-toxicity include:
- 5-fluorouracil (Adrucil)
- Paclitaxel (Taxol)
- Anthracyclines (a class of drugs)
- Targeted therapies: such as monoclonal antibodies and tyrosine kinase inhibitors.
- Some Leukemia drugs.
What drug can lead to cardiotoxicity?
Cytostatic antibiotics of the anthracycline class are the best known of the chemotherapeutic agents that cause cardiotoxicity. Alkylating agents such as cyclophosphamide, ifosfamide, cisplatin, carmustine, busulfan, chlormethine and mitomycin have also been associated with cardiotoxicity.
Is heart damage from Herceptin permanent?
In rare cases, heart failure develops. Heart function can recover when Herceptin treatment stops. Other research has shown that heart problems caused by Herceptin are more likely to happen in: older women.
What are the side effects of trastuzumab?
The most common side effects seen in treatment of metastatic breast cancer (based on intravenous trastuzumab) are fever, chills, headache, infection, congestive heart failure, insomnia, cough, and rash. Talk to a healthcare professional for more information about the benefits and risks of HERCEPTIN HYLECTA.
What kind of heart damage does Herceptin cause?
One of the known side effects of the breast cancer drug trastuzumab (Herceptin) is that it can damage the heart and its ability to pump blood effectively, sometimes resulting in mild heart failure, including shortness of breath and chest pain.
Is pertuzumab a cardiotoxic?
However, the cardiotoxic effect of pertuzumab, another HER2-directed therapy, is less well documented. The objective of this systematic review and meta-analysis was to determine the risk of cardiac events in patients with HER2-positive cancer who are receiving pertuzumab.
Which chemotherapy drug has heart failure as a serious toxicity?
New research suggests that the widely used chemotherapy drug doxorubicin may cause heart toxicity, potentially leading to congestive heart failure.
Why does cyclophosphamide cause cardiotoxicity?
The precise mechanism of cyclophosphamide-induced cardiac toxicity has not been established. Cyclophosphamide metabolites are believed to cause oxidative stress and direct endothelial capillary damage with resultant extravasation of proteins, erythrocytes, and toxic metabolites (Figure 2).
Which antineoplastic drug is most commonly associated with cardiotoxicity?
Which anticancer drug is cardiotoxic?
Anthracyclines, a class of chemotherapy drugs, are traditional cancer therapies that have been effective in treating many forms of cancer for the last half century. One of the most prominently used and readily identifiable is the anthracycline DOX. DOX-induced cardiotoxicity is classified as type I, or irreversible.
Can Herceptin cause heart damage?
Heart muscle damage and heart failure are potentially serious side effects of Herceptin. A small study has found that after 3 months of Herceptin treatment, nearly 58% of women had some loss of heart function.
How common are heart problems with Herceptin?
Which chemotherapy drug causes cardiotoxicity?
Which chemotherapy drugs damage the heart?
Chemotherapy drugs that can cause heart damage include:
- anthracycline drugs such as doxorubicin (Adriamycin), daunorubicin (Cerubidine, daunomycin) and epirubicin (Pharmorubicin)
- carboplatin (Paraplatin, Paraplatin AQ)
- paclitaxel (Taxol)
- cyclophosphamide (Procytox)
Why does Herceptin cause heart failure?
During Herceptin treatment, which is recommended for one year, toxicity can cause the heart to become too weak to pump blood. All patients on Herceptin undergo regular cardiac tests, such as an echocardiogram, to look for possible heart damage.
Can Herceptin cause heart failure?
Does Herceptin cause heart problems?
What kind of heart problems does Herceptin cause?
Herceptin use can cause heart problems, including heart failure, high blood pressure, and arrhythmia (irregular heart rhythm or heart rate). Receiving Herceptin with medications called anthracyclines can increase this risk.
Is trastuzumab associated with cardiotoxicity?
Cardiotoxicity has been associated with trastuzumab, and this issue has now been studied and documented in a number of adjuvant trials for which data have now been released.
Do anthracyclines and trastuzumab cause heart failure?
The pivotal, randomized multicenter phase III trial by Slamon and colleagues showed that combining trastuzumab with anthracyclines caused cardiac dysfunctions and heart failures in up to 27% of HER2-positive metastatic breast cancer patients compared with less than 7% in anthracyclines only group .
What is the mechanism of action of trastuzumab?
TRASTUZUMAB AND MECHANISMS OF ACTION Trastuzumab, a humanized monoclonal antibody directed against epidermal growth factor receptor 2 (HER2), has been approved to treat multiple oncologic conditions, including HER2-positive breast cancers in adjuvant, neoadjuvant, and metastatic settings and metastatic gastric cancer [1,2,3].
Does trastuzumab affect HER2-positive breast cancer?
Not unexpectedly, Akt activity, which was downregulated by trastuzumab in HER2-positive breast cancer cells , remained unchanged in cardiomyocytes treated with trastuzumab, suggesting that HER2 downstream signaling is differentially regulated by trastuzumab dependent on status of HER2 expression levels in cells.