What is the mechanism of action of atazanavir?
Atazanavir binds to the protease active site and inhibits the activity of the enzyme. This inhibition prevents cleavage of the viral polyproteins resulting in the formation of immature non-infectious viral particles. Protease inhibitors are almost always used in combination with at least two other anti-HIV drugs.
What is the mechanism of action of indinavir?
Mechanism of Action Indinavir acts through a competitive inhibition mechanism. The medication binds the active catalytic site of HIV protease, thereby inhibiting the enzyme’s ability to cleave polypeptides into active, infectious proteins.
Why is ritonavir combined with atazanavir?
Atazanavir/ritonavir is as effective as lopinavir/ritonavir, with a more favourable lipid profile and less gastrointestinal toxicity, in treatment-experienced HIV-1-infected patients. We compared these two combinations directly in treatment-naive patients.
Is atazanavir a CYP3A4 inhibitor?
Atazanavir is a known substrate and inhibitor of CYP3A4 in vitro. Therefore, medications that are also metabolized by CYP3A4 may interact with atazanavir.
What is the brand name for atazanavir?
Atazanavir (brand name: Reyataz) is a prescription medicine approved by the U.S. Food and Drug Administration (FDA) for the treatment of HIV infection in adults and children.
What class of drug is indinavir?
Indinavir is in a class of medications called protease inhibitors. It works by decreasing the amount of HIV in the blood. Although indinavir does not cure HIV, it may decrease your chance of developing acquired immunodeficiency syndrome (AIDS) and HIV-related illnesses such as serious infections or cancer.
What type of inhibitor is saquinavir?
Saquinavir is an HIV protease inhibitor with no, or limited, effect on the activity of other structurally related human aspartic proteinases.
How zidovudine can be synthesized?
Zidovudine is 3′-azido-3′-deoxytimidine (36.1. 26), is synthesized from 1-(2′-deoxy-5′-O-trityl-β-d-lyxosyl)thymine, which is treated with methansulfonyl chloride in pyridine to make the corresponding mesylate 36.1.
Which of the following describes the mechanism of action for AZT?
Which of the following describes the mechanism of action for AZT? it inhibits fusion of the viral envelope and host cell envelope.
What is atazanavir and ritonavir?
ATAZANAVIR+RITONAVIR belongs to the class of medications called ‘antiretroviral agents’ used to treat HIV infection. HIV is a virus that attacks the immune cells of the body leading to decreased immunity. It spreads through body fluids such as semen, vaginal fluid, and blood.
How is atazanavir given?
Atazanavir comes as a capsule and as a powder to take by mouth. Atazanavir capsules are taken with food once a day and may be given with a pharmacokinetic booster (medication given to increase the levels of another drug in the body) such as ritonavir or cobicistat.
What are CYP3A inhibitors used for?
A CYP3A inhibitor used to increase the systemic exposure of atazanavir or darunavir in combination with other antiretroviral agents in the treatment of HIV-1 infection. A viral protease inhibitor used in the treatment of HIV infection.
What is the most common side effect of atazanavir?
The most common adverse reactions were nausea, jaundice/scleral icterus, and rash.
What is atazanavir used for?
Atazanavir is used along with other medications to treat human immunodeficiency virus (HIV) infection in adults and children who are at least 3 months of age and weigh at least 22 lb (10 kg). Atazanavir is in a class of medications called protease inhibitors. It works by decreasing the amount of HIV in the blood.
Is atazanavir an antibiotic?
Reyataz (atazanavir sulfate) is an antiviral medication in a group of HIV medicines called protease inhibitors used to treat HIV, which causes acquired immunodeficiency syndrome (AIDS).
Who manufactures indinavir?
Indinavir (IDV; trade name Crixivan, made by Merck) is a protease inhibitor used as a component of highly active antiretroviral therapy to treat HIV/AIDS.
What is the generic name for indinavir?
CRIXIVAN® (indinavir sulfate) is an inhibitor of the human immunodeficiency virus (HIV) protease.
What is the mechanism of action of saquinavir?
Mechanism of Action Saquinavir is an inhibitor of HIV protease. HIV protease is an enzyme required for the proteolytic cleavage of viral polyprotein precursors into individual functional proteins found in infectious HIV.
What is saquinavir used for?
Descriptions. Saquinavir is used together with ritonavir (Norvir®) and other antiviral medicines for the treatment of human immunodeficiency virus (HIV) infection. HIV is the virus that causes acquired immune deficiency syndrome (AIDS).
How would you synthesis zidovudine from thymidine?
Zidovudine is 3′-azido-3′-deoxytimidine (36.1. 26), is synthesized from 1-(2′-deoxy-5′-O-trityl-β-d-lyxosyl)thymine, which is treated with methansulfonyl chloride in pyridine to make the corresponding mesylate 36.1. 24.
What is the mechanism of action of the antimicrobial AZT quizlet?
Can atazanavir be used alone?
Pharmacology. Although atazanavir can be administered alone to treatment-naive patients who cannot tolerate ritonavir, it is preferably co-administered with low-dose ritonavir to optimize its pharmacokinetic parameters and efficacy (Table 1) [5].