What drugs are affected by cytochrome P450?
Examples of Common Drug-Drug Interactions Involving the Cytochrome P450 Enzyme System
| Drug(s)/product | Enzyme inhibitor or inducer |
|---|---|
| Fluoxetine (Prozac), paroxetine (Paxil), | CYP2D6 inhibitor |
| Grapefruit juice | CYP3A4 inhibitor |
| Metronidazole (Flagyl) | CYP2C9 inhibitor |
| Terbinafine (Lamisil) | CYP2D6 inhibitor |
Is Nadph a cytochrome?
Abstract. NADPH cytochrome P450 reductase (CPR) is essential for cytochrome P450 catalysis, which is important in the detoxification and activation of xenobiotics.
Which is facilitating electron transfer from Nadph to cytochrome P450?
NADPH-cytochrome P450 oxidoreductase (CYPOR) catalyzes the transfer of electrons to all known microsomal cytochromes P450. A CYPOR variant, with a 4-amino acid deletion in the hinge connecting the FMN domain to the rest of the protein, has been crystallized in three remarkably extended conformations.
What is the role and importance of cytochrome P450?
Cytochromes P450 (CYPs) are a superfamily of enzymes containing heme as a cofactor that functions as monooxygenases. In mammals, these proteins oxidize steroids, fatty acids, and xenobiotics, and are important for the clearance of various compounds, as well as for hormone synthesis and breakdown.
What is function of cytochrome P450?
Background: The cytochrome P450 (CYP) enzymes are membrane-bound hemoproteins that play a pivotal role in the detoxification of xenobiotics, cellular metabolism and homeostasis. Induction or inhibition of CYP enzymes is a major mechanism that underlies drug-drug interactions.
What are CYP450 inducers?
CYP450 inducers reduce the concentration of drugs metabolised by the CYP450 system. The mnemonic CRAP GPs can be used to easily remember common CYP450 inducers.
What is the role of cytochrome oxidase?
Significance. Cytochrome oxidase is a widespread respiratory enzyme that conserves energy released when oxygen is reduced by pumping protons across the membrane in which it is located.