What is the difference between first line and second line TB drugs?
The first-line therapeutic drugs are the most effective and least toxic for use in the treatment of TB, while the second-line therapeutic drugs are less effective, more expensive and have higher toxicities. They are however, essential for the treatment of drug resistant forms of the bacteria (MDR-TB).
WHO TB drug doses?
Weight-based oral anti-TB drug daily dosing in adults ≥30 kg
DRUGS | DAILY DOSE | >70 KG |
---|---|---|
Isoniazid | 4–6 mg/kg once daily | 300 mg |
Rifampicin | 8–12 mg/kg once daily | 600 mg |
Pyrazinamide | 20–30 mg/kg once daily | 2000 mg |
Ethambutol | 15–25 mg/kg once daily | 1200 mg |
Why is TB treated with 4 drugs?
The standard of care for initiating treatment of TB disease is four-drug therapy. Treatment with a single drug can lead to the development of a bacterial population resistant to that drug. Likewise, the addition of a single drug to a failing anti-TB regimen can lead to additional resistance.
What is a second line treatment?
Second-line treatment is treatment for a disease or condition after the initial treatment (first-line treatment) has failed, stopped working, or has side effects that aren’t tolerated. It’s important to understand “lines of treatment” and how they differ from first line treatment and can play a role in clinical trials.
What is a second line antibiotic?
The most commonly used second-line therapies include amoxicillin/clavulanate, second- or third-generation cephalosporins (eg, cefuroxime, cefpodoxime, cefdinir), macrolides (ie, clarithromycin), fluoroquinolones (eg, ciprofloxacin, levofloxacin, moxifloxacin), and clindamycin.
How many TB tablets should I take?
For the treatment of tuberculosis: Adults and children 15 years of age and older weighing 55 kilograms (kg) (121 pounds) or more—6 tablets per day. Adults and children 15 years of age and older weighing between 45 and 54 kg (99 and 119 pounds)—5 tablets per day.
How do you take Myrin P Forte?
Pyrazinamide + Ethambutol HCl + Rifampicin + Isoniazid (Myrin-P Forte) should be taken 1 hour before or 2 hours after a meal. Should gastrointestinal irritation occur, the combination may be taken with food or antacids, but not aluminum-containing antacids.
What are the 4 TB drugs?
Rifampin (RIF),
How do you take AKT 4 drugs?
Directions for Use Take A K T 4 Kit Tablet 30minutes before food or 2hours after food. Swallow A K T 4 Kit Tablet as a whole; do not crush or chew the tablet. The dose and duration of A K T 4 Kit Tablet can vary depending upon your condition and severity of the infection.
What is 2nd line?
“Second lining” is a highly recognizable strutting, chicken-like dance move that many people use to keep pace with the band. So “second line” is a term with many meanings; it applies to a type of parade, a part of the parade, and a dance move used within that parade.
Why is it called the second line?
The Second Line – the magazine of the New Orleans jazz club, started in 1950 – took its name from the second lining tradition, which by that time included fans of jazz music, both black and white.
When do you need a second-line of antibiotics?
Second-line antibiotics should be considered when the patient has moderate disease, has used antibiotics in the past six weeks, or has no response to treatment within 72 hours.
How do I take Myrin tablet?
Ethambutol HCl / Rifampicin / Isoniazid (Myrin) should be taken 1 hour before or 2 hours after a meal. Should gastrointestinal irritation occur, the combination may be taken with food or antacids, but not aluminum-containing antacids.
What is rifampin 150 mg used for?
Rifampin is used with other medications to treat tuberculosis (TB; a serious infection that affects the lungs and sometimes other parts of the body).
What is Rifampicin 150 mg used for?
Tuberculosis: Rifampicin, used in combination with other active anti-tuberculosis drugs, is indicated in the treatment of all forms of tuberculosis, including fresh, advanced, chronic and drug-resistant cases. Rifampicin is also effective against most atypical strains of mycobacteria.
How many days AKT 4 should be taken?
AKT 4 is usually taken for 2 to 3 months and then maintenance therapy with 2 drugs for 4 to 6 months. That is the standard antitubercular treatment. The liver function needs to be monitored regularly during this times as the meds may affect liver. The symptoms could be due to deranged LFT.
When should I take AKT 4 tablet?
Take Akt 4 Kit on an empty stomach which means at least one hour before and two hours after a meal and with full glass of water.
How much is 2ndLine?
The 2ndLine app provides you flexible pricing options to keep your number active. If you are in the US, it can be purchased for $4.99 for the first month, then $9.99 subsequently. It can be purchased for less – $69.99 if you opt for a yearly option.
Why is it called 2ndLine?
What are second line drugs for TB?
Second line drugs are the TB drugs that are used for the treatment of drug resistant TB.
How many drugs are currently approved for treating tuberculosis (TB)?
There are 10 drugs currently approved by the U.S. Food and Drug Administration (FDA) for treating TB. Of the approved drugs, the first-line anti-TB agents that form the core of treatment regimens are:
Who should take the second line drugs?
All the second line drugs should only be used under the supervision of an experienced doctor. Their use needs to take into account not only the World Health Organisation (WHO) recommendations, but also what is recommended by a country’s National Treatment Program.
What is the first-line treatment for tuberculosis (TB)?
Of the approved drugs, the first-line anti-TB agents that form the core of treatment regimens are: isoniazid (INH) rifampin (RIF) ethambutol (EMB) pyrazinamide (PZA)