Is granulosa a cancerous tumor?
Granulosa cell tumor of the ovary is a rare type of ovarian cancer. This type of tumor is known as a sex cord-stromal tumor and usually occurs in adults. Granulosa cell tumors of the ovary cause higher than normal levels of estrogen in a woman’s body.
Is granulosa cell tumor ovarian cancer?
Ovarian granulosa cell tumor (GCT) is a malignant tumor originating from the sex-cord stromal cells of the ovary. It is an uncommon primary malignant tumor of the ovary and represents 2% to 5% of all ovarian cancers [1].
What is granulosa of the ovary?
Granulosa cells are inside your ovaries. These cells produce estrogen, progesterone and other hormones. The hormones play a large part in the female reproductive system, from menstruation to ovulation to egg implantation.
What is a granulosa cell ovary?
What is the treatment for granulosa cell tumor of the ovary?
Treatment consists of surgery to remove the tumor, and additional treatments may also be used depending on the extent of the tumor. Treatment Treatment. Surgery is the first step of treating a granulosa cell tumor of the ovary and aims to remove as much of the tumor as possible.
What is the prevalence of ovarian granulosa cell tumors?
Granulosa cell tumors account for approximately 2 percent of all ovarian tumors. Granulosa cell tumors are thought to be tumors of low malignant potential. Most of these tumors follow a benign course, with only a small percentage showing aggressive behavior, perhaps due to early stage at diagnosis.
What is a granulosa cell tumor?
Granulosa cell tumors are considered stromal tumors and include those composed of granulosa cells, theca cells, and fibroblasts. Granulosa cell tumors account for approximately 2 percent of all ovarian tumors. Granulosa cell tumors are thought to be tumors of low malignant potential.
How is estradiol produced in granulosa cell tumors?
This estradiol production is dependent on stimulation by testosterone secreted by the theca cells. However, not all granulosa cell tumors are hormonally active or have theca cells that secrete testosterone, and this type of testing lacks sensitivity and specificity.