Who makes amifostine?
Amifostine (ethiofos) is a cytoprotective adjuvant used in cancer chemotherapy and radiotherapy involving DNA-binding chemotherapeutic agents. It is marketed by Clinigen Group under the trade name Ethyol.
What class of drug is amifostine?
OrganothiophosphateAmifostine / ClassificationOrganothiophosphates or organophosphorothioates are a subclass of organophosphorus compounds. Many are used as pesticides, some have medical applications, and some are used as oil additives. They generally have the chemical formula (RO)₃PS, [(RO)₂PO]⁻, R(RO)₂PS, etc. Wikipedia
How does amifostine work?
Amifostine is thought to work by preventing certain chemicals from damaging healthy cells. It may also help repair cells damaged by cisplatin or radiation treatment.
How is amifostine administered?
Amifostine is given in to a vein (intravenous, IV) infusion starting about 15-30 minutes before chemotherapy or radiation therapy is scheduled to begin. Before amifostine is given, patients must drink plenty of fluids. Patients receive this medicine lying down, facing up, and blood pressure is monitored frequently.
Is amifostine FDA approved?
Amifostine Trial Represents First FDA Approval of Treatment Interacting With Radiation.
Is amifostine still used?
Based upon these findings, amifostine was approved for use as a radiation protection agent by the FDA for the reduction of xerostomia in pa- tients receiving postoperative head and neck radiation therapy. Till today, amifostine remains the first and only radiation protector that is FDA approved for clinical use.
When should I take amifostine?
Amifostine is used protect the kidneys from harmful effects of the chemotherapy drug cisplatin in patients that receive this medication for the treatment of ovarian cancer. Amifostine is also used to decrease dryness in the mouth caused by radiation treatment after surgery for head and neck cancer.
When do you give amifostine?
Amifostine is given by intravenous (into a vein) infusion. The treatment is given before radiation or chemotherapy starts. Patients are given the infusion while lying down and their blood pressure is monitored frequently. Patients may be asked to increase their fluid intake for 24 hours before the infusion.
Which of the following adverse effects have been reported with Ethyol treatment?
Common side effects may include:
- nausea, vomiting;
- flushing (warmth, redness, or tingly feeling);
- fever, chills, general ill feeling;
- rash;
- dizziness, drowsiness;
- hiccups, sneezing;
- blurred vision, double vision; or.
- pain, itching, redness, bruising, or swelling around the IV needle.
Is leucovorin folic acid?
Leucovorin is in a class of medications called folic acid analogs. It works by protecting healthy cells from the effects of methotrexate or similar medications while allowing methotrexate to enter and kill cancer cells.
Is Avastin safe?
More serious side effects have been experienced in a small percentage of people taking Avastin, including blood clots in a vein, slow wound healing, perforation of the intestines, higher risk of stroke or heart problems, kidney malfunction, and reduced white blood cell count.
How long can Avastin be taken?
And you keep taking Avastin as long as your disease is controlled and your side effects are manageable, up to 22 cycles. By continuing to take Avastin, you may be able to continue to control your cancer.
What foods are good for mucositis?
What you can do: Improving your eating when you have mucositis
- Try freezing fruits and suck on frozen fruit pops, fruit ice or ice chips.
- Eat soft, creamy foods.
- Blend and moisten foods that are dry or solid.
- Puree or liquefy foods in a blender to make them easier to swallow.
What is leucovorin used for?
Leucovorin is used as an antidote to the harmful effects of methotrexate (a cancer medicine) that is given in high doses. It is used also to prevent or treat certain kinds of anemia. Leucovorin acts the same way in the body as folic acid, which may be low in these patients.
Is leucovorin safe?
Leucovorin may cause serious side effects including: hives, difficulty breathing, swelling of your face, lips, tongue, or throat, and.
Can Avastin cause death?
The study found that compared with chemotherapy alone, the addition of Avastin was associated with a 1.46 times increase in the risk of a fatal adverse event. Internal bleeding in the gut and lungs accounted for most deaths.