What is ethacrynic acid used for?
Ethacrynic acid belongs to a group of medicines called loop diuretics or “water pills.” Ethacrynic acid is given to help treat fluid retention (edema) and swelling that is caused by congestive heart failure, liver disease, kidney disease, or other medical conditions.
What is the indication of Metolazone?
Metolazone tablets are indicated for the treatment of salt and water retention including: edema accompanying congestive heart failure; edema accompanying renal diseases, including the nephrotic syndrome and states of diminished renal function.
What is the classification of ethacrynic acid?
PhenoxyacetatesEtacrynic acid / Classification
What are the side effects of Ethacrynic?
Ethacrynic acid may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
- frequent urination (should not last longer than a few weeks)
- nausea.
- vomiting.
- loss of appetite.
- stomach pain.
- difficulty swallowing.
- loss of appetite.
- thirst.
Which actions are related to ethacrynic acid?
The primary action of ethacrynic acid is the inhibition of the activity of the Na⁺-K⁺-2Cl⁻ symporter in the thick ascending limb of the loop of Henle. The onset of action is usually within 30 minutes after an oral dose and within 5 minutes after an intravenous injection.
Is ethacrynic acid ototoxic?
Results indicated an ototoxic effect of ethacrynic acid in concentrations of 30 and 50 mg/kg, and in concentrations of 10 mg/kg if the doses were repeated in two hours. Ethacrynic acid inhibits active ion transport in the tissues of the cochlear duct. This is manifested by a drop in EP, CM, and AP.
Does ethacrynic acid lower blood pressure?
Ethacrynic acid (Edecrin) lowers your blood pressure and can make you feel lightheaded or dizzy.
Can ethacrynic acid be given IV?
Intravenous SODIUM EDECRIN is for intravenous use when oral intake is impractical or in urgent conditions, such as acute pulmonary edema. The usual intravenous dose for the average sized adult is 50 mg, or 0.5 to 1.0 mg per kg of body weight.
What is lactulose used for and side effects?
Description and Brand Names Lactulose is used to treat constipation. It helps increase the number of bowel movements per day and the number of days on which bowel movements occur in patients with a history of chronic (long-lasting) constipation. This medicine is available only with your doctor’s prescription.
What are the contraindications of lactulose?
Who should not take LACTULOSE?
- diabetes.
- appendicitis.
- blockage of the stomach or intestine.
- galactosemia.
- glucose-galactose malabsorption.
Does ethacrynic acid cause ototoxicity?
Is ethacrynic acid potassium sparing?
Although ethacrynic acid, in carefully controlled studies in animals and experimental subjects, produces a more favorable sodium/potassium excretion ratio than the thiazides, in patients with increased dieresis excessive amounts of potassium may be excreted.
What are the indications of diuretics?
Diuretics are indicated for treating:
- Oedema.
- Congestive heart failure.
- Hypertension.
- Renal disease.
- Liver disease.
- Glaucoma.
- Raised intracranial pressure.
Why do you give metolazone before furosemide?
Even at low doses metolazone significantly potentiates the diuretic effects of furosemide and therefore simplifies the treatment of fluid retention. High doses of furosemide can be avoided in many cases, a factor of particular advantage in ambulatory long term therapy and in patients with decreased kidney function.
Is ethacrynic acid a sulfa drug?
Ethacrynic acid is the only loop diuretic on the US market that does not contain a sulfonamide substituent.
How do you take ethacrynic acid?
Intravenous Use. Intravenous SODIUM EDECRIN is for intravenous use when oral intake is impractical or in urgent conditions, such as acute pulmonary edema. The usual intravenous dose for the average sized adult is 50 mg, or 0.5 to 1.0 mg per kg of body weight.
What is the purpose of lactulose?
Lactulose is a synthetic sugar used to treat constipation. It is broken down in the colon into products that pull water out from the body and into the colon. This water softens stools. Lactulose is also used to reduce the amount of ammonia in the blood of patients with liver disease.
What is lactulose used for?