Organ growing Part 1
Many diseases, including life threatening, are associated with dysfunction of a specific organ (kidney failure, heart failure, diabetes, etc.). Not in all cases, these violations can be corrected through traditional pharmacological or surgical stress.
There are a number of alternative ways to restore the function of organs to patients in the event of a serious defeat:
Stimulation of regeneration processes in the body. In addition to pharmacological effects in practice, the procedure of introduction into the body of stem cells that have the ability to transform into functional cells of the body. Already obtained positive results in the treatment with stem cells of a variety of diseases, including the most common in the society of diseases, such as heart attacks, strokes, neurodegenerative diseases, diabetes, and others. However, it is clear that this method of treatment is applicable only to resolve a relatively small damage to the organs.
Fill the functions of organs using machines not of biological origin. It could be the large dimensions of the devices that connect patients at a certain time (for example, devices for hemodialysis in renal failure). There are also models of wearable devices, or devices implanted into the body (there are options to do it, leaving their own on the patient, however, sometimes it is removed, and the machine completely takes over its functions, as in the case of the use of artificial hearts AbioCor). These devices are in some cases used for timeout to happen, you need a donor organ. Until biological counterparts are vastly inferior to the perfection of natural bodies.
The Use of donor organs. Donor organs transplanted from one person to another, is already widely and successfully used in clinical practice. However, this direction faces a number of challenges, such as serious shortage of donor organs, the problem of rejection of foreign organ by the immune system etc. have Already been attempts to transplant human organs of animals, but so far successes in the application of this method is modest and regular practice it is not implemented. However, research is being conducted with the aim to increase the efficiency of xenotransplantation, for example, by genetic modification.
Growing organs. Organs can be grown artificially in the human body and outside the body. In some cases, there is the ability to grow on cells of the person it’s going to transplant. Developed a number of methods of growing biological organs, for example, with the help of special devices working on the principle of 3D printer. To this direction include the proposal to allow the cultivation to replace the corrupted human body with the preserved brain, self-developing organism, a clone is “plant” (disabled ability to think).
Among these four solutions to the problem of insufficiency of organ functions is their cultivation can be most natural for the body recovery method for large damage.
In the present text provides information on existing achievements in growing biological organs.
Restoration of damaged areas of the skin is already part of clinical practice. In some cases methods are used, the regeneration of the skin of the person, for example, affected by the burn special effects. This example developed by R. R. Rahmatullin bioplastic material, developed by a team under the leadership. For growing skin for burn also uses a special.
Also developing methods for the printing of pieces of skin tissue using special printers. These technologies do, for example, the developers of the U.S. centers of regenerative medicine.
Dr. Gerlach (Jorg Gerlach) with colleagues from the Institute for regenerative medicine at the University of Pittsburg (Institute for Regenerative Medicine at the University of Pittsburg) invented the device for skin transplantation which will help people to recover faster from burns of varying severity. Skin Gun sprays on damaged skin affected solution with his own stem cells. At the moment the new treatment is in the experimental stage, but results are already impressive: severe burns to heal in a couple of days.
Some employees at Columbia college below the assistance of Gordana Vunjak Novakovic got by stem cells piled over the framework, also a bone fragment, very similar to portions of their temporomandibular joint.
Boffins of this Israeli corporation reward (creator and Executive Director based Meretzki Shai) are all growing means for improving individual bone out of nitric tissues got during operation. So improved bone has been already successfully ventured into the rat paw.
Italian experts in the University of Udine surely could prove that the consequences gained by the tissues of nitric tissue that a populace of mesenchymal stem cells from vitro even in the lack of certain structural matrix or parasite might be discerned in arrangement, including a dental Bud.
In Tokyo college, also have increased out of stem cells from the torso teeth full of bone, dental and connective tissues, and then successfully implanted them in the branches of creatures.
To begin with, the investigators eliminated the critters the ribs of the shoulder joint, and under it's a coating of bone marrow. Subsequently from the area of tissue that was removed, they've been put into hydration scaffolds.
Those critters whose skeletons incorporate altering growth factor a protein which modulates the differentiation and development of cells, just formed cartilage and bone at the shoulder joints, and movements at the joint has now fully regained.
The band of Western scientists in your University of Texas At Austin were able to progress at the invention of cartilage changing in various regions of the mechanical components and makeup of their extracellular matrix.
Back in 1997, the Surgeon Vacanti Jay at this most important healthcare facility of Massachusetts at Boston was able to rise to the rear part of the mouse an individual ear with cells of cartilage.
Doctors in Johns Hopkins taken out the tumefaction ear and also the portion of the skull by an 42 year old lady afflicted by cancer. Utilizing cartilage out of the rib cage, your epidermis and bloodstream from different regions of your human anatomy of their individual, they increased her mouth into his ear onto his arm and then then awakened into the desirable spot.